Description Introduction Expert Advice Indication: This medication is used to treat severe malaria including cerebral malaria and as a second line treatment in chloroquine resistant falciparum malaria Contraindication: This medication is contraindicated in patients with history of arrhythmias (abnormal heart rhythm), bradycardia (slow heart rate), and congestive heart failure Side effects: The patients taking this medication may experience abdominal pain, anorexia (eating disorder), diarrhea, vomiting, nausea, and dizziness. If you experience any of these symptoms for a long period of time, consult your doctor immediately Precautions: The patients taking this medication must be cautious in cases of electrolyte disturbance, use with other drug that causes prolonged QT interval (heart muscles take longer than usual to recharge between beats), dizziness, severe cardiac (heart) or renal (kidney) impairment Interaction: This medication may interact with inhibitors of CYP3A4, substrates of CYP262D, grapefruit juice, class Ia III antiarrythmics (prevents abnormal heart rhythm), antidepressants, antimalarials, gormonal contraceptives, azole anti-fungal and antipsychotics (treats bipolar disorder) Pregnancy: This medication is contraindicated in pregnancy Lactation: This medication is contraindicated in lactation Primary Uses Malaria Indications This medicine is used in the treatment of severe malaria including cerebral malaria and as a second line treatment in chloroquine resistant falciparum malaria. Side Effects Patients using this medication may at times experience abdominal pain, anorexia (eating disorder), diarrhea, vomiting, nausea, and dizziness. If you experience any of these symptoms for a long period of time, consult your doctor immediately.
